Studies

Nervous system influences on recovery from painful rotator cuff tears

Rotator Cuff Tears

This study aims to elucidate the factors between structural damage, pain severity, and functional recovery in individuals with a rotator cuff tear (traumatic, chronic or asymptomatic).

NIAMS R01 AR080058-01A1
PI: F. Pozzi
Role: Co-I
2023-2028

Shoulder pain

Racial and socioeconomic differences in chronic low back pain

ERASED

This study examines disparities in clinical symptoms, experimental pain sensitivity, and psychosocial risk factors, over a two-year period among individuals with chronic low back pain.

NIMHD 1R01MD017565 – 01A1
PI: B. Goodin
Role: Co-I
2023-2008

Low Back Pain

Study on medical marijuana and its long term effects in older adults

SMILE

This study examines the short and long term effects of medical marijuana on pain, physical, emotional, and cognitive functioning and quality of life in older adults.

NIA 1 R01 AG071729-01A1
PI: Y. Wang
Role: Co-I
04/01/22-03/31/27

marijuana

Protective Resilience Index for Successful Aging in Musculoskeletal Pain

PRISM

The project will refine and confirm the components of a clinically applicable resilience index with consideration for sociodemographic group differences (sex and ethnicity/race).

RCCN: Inter-NIA Center Pilot Proposal Life Course Perspectives on Aging & Resilience & Reserve in Aging
MPI: K. Sibille
, E. Bartley, &
A. Brooks
06/01/21-05/31/23 NCE

resilience

Chronic Pain Severity, Biomarkers of Dementia, Ethnicity/Race Predicting AD Vulnerabilities

AD and Biomarkers

The goal of this study is to better understand relationships between ethnicity/race groups, chronic pain severity, and dementia-related risk factors including changes in brain structure over a two-year period.

Administrative Supplement
NIA R01 AG054370
CO-PIs: K. Sibille, J. Tanner
09/1/2020-08/31/22 NCE

Brain

Biobehavioral Basis of Knee Osteoarthritis Pain

Biobehavioral Factors

This project will collect data from two previous studies to discover and validate age-related biomarkers and clinical endpoints for pain.

NIA 1 R01 AG067757-01
PI: Y. Cruz-Almeida

Role: Co-I
07/01/20–06/30/25

brain

Pain Relief for OsteoArthritis through Combined Treatment

PROACT

This project examines the effect of a five day course of meditation and transcranial direct current stimulation on pain modulatory balance and pain-related brain function and chronic pain in older adults with knee osteoarthritis.

NIA 2 R37 AG033906-16
PI: R. Fillingim
Role: Co-I
9/15/19-04/31/24

Knee pain

UNDERSTANDING PAIN AND LIMITATIONS IN OSTEOARTHRITIC DISEASE (UPLOAD)-2

UPLOAD-2 Health Disparities

This project investigates the trajectory from stress exposure to biological measures of aging and stress-related system dysregulation (allostatic load, telomere length, changes in brain structure/function) to ethnic/race differences in osteoarthritis-related health outcomes over a six-year period.

NIA R01 AG054370            
PI
: K. Sibille
09/15/16 – 05/31/23 NCE

knee pain

Completed Studies

Adaptability and Resilience in Aging Adults

ARIAA

The study tested the feasibility and acceptability of a resilience intervention in older adults with chronic back pain, explored if the intervention engages proposed targets, and assessed pain outcomes.

NIA R00AG05642
PI: E. Bartley
Role: Co-I
09/15/18-09/14/22 NCE

back pain

Curcumin and Function in Older Adults

SPICE

This study investigated if the dietary supplement curcumin maintains or improves physical and cognitive function in aging adults who are at increased risk for disability.

Co-PIs: S. Anton, R. Mankowski
Role: Co-I
07/01/17-06/30/19

curcumin

Emotional Engagement Driven by Complex Visual Stimuli

NEURAL DYNAMICS -MULTIMODAL IMAGING

This study characterized brain network dynamics to emotional cues under quasi-naturalistic conditions server.

Co-PIs: M. Ding, A. Keil
Role: Co-I
04/01/17-03/31/22

brain network

Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness

OPTIMIZE

The purpose of the pilot study was to test the feasibility and acceptability of intermittent fasting and glucose administration paired with a recognized pain treatment activity, relaxation and guided imagery.

American Pain Society-Sharon S. Keller Chronic Pain Research Grant & UF CTSI Pilot Award
PI: K. Sibille
06/01/14 – 12/30/17

food

UNDERSTANDING PAIN AND LIMITATIONS IN OSTEOARTHRITIC DISEASE

UPLOAD

This study examined ethnic/race group differences in clinical symptoms, psychosocial functioning, and pain after baseline and over a four-year follow-up period among older adults with knee osteoarthritis.

NIA 2 R37 AG033906
PI: R. Fillingim
Role: Co-I
09/15/14 – 04/30/19

knee pain image

Biological Markers of System Burden in Symptomatic Knee OA: A Prospective Study

UPLOAD FollowUp

The objectives of the study are to prospectively evaluate associations of pain and functional limitations with a developing measure of system burden in ethnically diverse older adults with and without knee OA and explore the role of various biopsychosocial factors that may be protective or increase vulnerability for pain and functional decline.

NIAMS K23 AR062099
PI: K. Sibille
04/01/13 – 03/31/18

Knee pain

Assessing the impact of Chronic Pain on Biological Measures of System Burden and Cellular Aging

Pain Related System Burden

The project involved investigating the effects of chronic pain on biological functioning (system burden), and exploring associations with pain sensitivity, functioning, and disease progression (chronic pain severity).

IASP-Foundation by Inger & Jens Bruun Funding
PI: K. Sibille
06/30/12 – 09/30/18

chronic pain

Biological Markers of System Burden in Symptomatic OA

OA Biomarkers

The purpose of the study was to better understand the interaction between biological processes, chronic pain, and biopsychosocial variables among ethnically diverse older adults with and without symptomatic knee osteoarthritis; and 2) to determine associations between baseline telomere measures and psychological and functional measures at 24 months.

NIH/NCRR CTSA UL1RR029890 and KL2 TR000065
PI: K. Sibille
12/01/11-03/01/13

knee

Effects of Chronic Pain and Psychosocial Stress on Telomere Length and Telomerase Activity

Pain and Stress

The purpose of the study was to better understand the interaction between biological processes, chronic pain, and biopsychosocial variables among ethnically diverse older adults with and without symptomatic knee osteoarthritis; and 2) to determine the potential clinical and predictive utility of telomere biomarkers.

American Pain Society Future Leaders in Pain Research Grant Program
PI: K. Sibille
01/01/11-06/01/12

tube

Measuring Stress System Overload – Telomere Length and Telomerase

Stress System Overload

The purpose of the study was to evaluate the biological interface of behavioral and social variables in ethnically diverse older adults with and without chronic OA-related pain, determine the utility of telomere length and telomerase activity as tools in assessing system overload resulting from chronic pain and/or other biopsychosocial variables, and to identify vulnerability and resilience factors.


NIH/NIA 3 R01 AG0333906 07S1 – ARRA OppNet Competitive Revision
Co-PIs: R Fillingim, K Sibille

09/01/10-08/01/11

blood